3D Printing for the Release of Therapeutic Peptides

3D Printing for the Release of Therapeutic Peptides

Chemistry

Zameer Ashrif

2024

Dave Haddleton Group

Active-ingredient loaded structures, integrated with reversibly covalently linked peptide, were fabricated using digital light processing (DLP) type VAT photopolymerization, in the absence of water. Bisacryloyl crystamine (BAC) was incorporated into printing resin for the introduction of disulfide functionality into some crosslinks. The uptake and subsequent release of lanreotide was monitored and facilitated via a reversible thiol-disulfide exchange controlled by addition of tris(2-carboxyethyl) phosphine (TCEP). The method was successful in cost and time efficiently producing structures capable of controlled release of a therapeutic peptide.

Polymer Chemistry, 3D Printing, Reversible Chemistry, Drug Delivery