Image Denoising via Neural Network Techniques
Calibrating the Night-Sky Quality at The Marsh Observatory
3D Printing Models of the Hyperbolic Plane
Impact of Maritime Piracy on Crude Oil Price Volatility
'Cross-ratio degree problems for 7 and 8 points in projective space'
Refining novel genetic biosensors for neuroactive chemicals based on in vivo detection of hydrogen peroxide.
My supervisor’s research team is investigating how neurons and glial cells communicate with each other, and to detect the release of L-Aspartate from neurons, they are expressing L-aspartate oxidase (LAOx) on the surface of mouse brain cells which generates hydrogen peroxide (H2O2) as one of the products. However, this production of H2O2 would not normally occur in brain, and therefore, it could have undesirable physiological effects. Catalase is an enzyme which metabolizes H2O2 and it could be combined in a construct with LAOx to prevent excessive accumulation of H2O2 in tissue. Microbial catalases with a high catalytic activity and a small mass would be appropriate. Such catalases could be expressed in ordered arrangements with LAOx and fluorescent proteins on mouse brain cell membranes to reduce the diffusion of H2O2 away from the detecting cells. My project therefore devised a range of constructs that combine catalase and LAOx tagged with a red fluorescent protein (mCherry) in different sequential orders to optimize oxidase-based biosensors for use in brain without overly reducing their sensitivity.
Will an independent English Football Regulator help to sustain ‘The Beautiful Game’ in England?
Teaching Boys to Cook in Twentieth Century Britain
This website looks at the changing provision of the teaching of basic cooking skills to boys in twentieth century Britain