Exploring The Impact of Biological Fluids on Lateral Flow Glyco-Assays

Exploring The Impact of Biological Fluids on Lateral Flow Glyco-Assays

Life Sciences

Megan Ellis

2024

Dr. Alex Baker, Zaimire Maimaitiaili

This research investigates how biologically relevant fluids affect the performance of lateral flow glyco-assays. Building on previous work by Baker et al., two glycosylated polymers, 40 and 72 length, were synthesised and used to functionalise 16nm gold nanoparticles (AuNPs). These fully functionalised nanoparticles were then incorporated into buffer solutions doped with biological fluids—blood, saliva, and urine and tested against differing concentrations of SBA and bovine serum albumin (BSA) (control group, no affinity for Gal-PHEA).

Megan Ellis, Lateral Flow, Polymers, Chemistry, Lateral Flow Glyco Assays, covid-19, covid