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              <text>Ruthenium(II) polypyridyl complexes are promising alternatives to platinum-based anticancer drugs due to their tunable photophysical properties and reversible DNA interactions. This study reports the synthesis, characterisation, and DNA-binding analysis of [Ru(dmbpy)₂(tpphz)]²⁺. The complex was successfully prepared and confirmed using 1H NMR, IR, UV-Vis, and mass spectrometry. UV-Vis spectra revealed characteristic MLCT bands near 450 nm, while DNA titrations showed hypochromism and red shifts, indicating intercalation. Luminescence studies demonstrated a ‘light-switch’ effect upon DNA addition, consistent with increased emission in the bound state. The binding constant (K_b ≈ 3.9 × 10⁵ M⁻¹) and low quantum yield (Φ ≈ 2%) suggest moderate affinity but promising photoactive potential. Overall, [Ru(dmbpy)₂(tpphz)]²⁺ exhibits characteristics desirable for further investigation as a potential photoactivated anticancer agent.</text>
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                <text>Synthesis, Characterisation and DNA binding studies of [Ru(dmbpy)(tpphz)] for Potential Anti-Cancer Applications</text>
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              <text>Sleep disorders, including obstructive sleep apnoea (OSA), narcolepsy type 1 (NT1), and sleep deprivation (SD), are linked to dementia and cognitive decline. The glymphatic system, a brain clearance pathway active during slow-wave sleep, has been proposed as a mechanistic link, though its role remains debated. We conducted a systematic review and meta-analysis of preclinical and clinical studies to evaluate associations between sleep disturbances, glymphatic dysfunction, and cognition. Sleep disorders were consistently associated with impaired glymphatic clearance, with the strongest effects in OSA, supported by dose–response and cognitive analyses. These findings highlight sleep disorders as prevalent, treatable, and potentially modifiable risk factors for dementia, underscoring the public health importance of sleep in maintaining brain health.</text>
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                <text>Ruth Whitehouse </text>
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                <text>Professor Johannes Boltze </text>
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                <text>Systematic review and meta-analysis of glymphatic dysfunction in sleep disorders and cognitive outcomes</text>
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                <text>Systematic review and meta-analysis of glymphatic dysfunction in sleep disorders and cognitive outcomes</text>
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                <text>Tail Asymptotics of the Signature of various stochastic processes and its connection to the Quadratic Variation&#13;
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                <text>Statistics </text>
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                <text>Martin Gbur</text>
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