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              <text>How can we accurately detect and locate a modification on an RNA molecule using nanopore sequencing data? This is an open problem that requires ideas from both statistics and biology. Supervised by Professors Anastasia Papavasiliou and Jon Forster, I began by simulating the signal data from Oxford Nanopore devices, where a sliding window reads five bases on the mRNA chain at a time. Using R, we constructed a statistical framework which involves working with different distributions such as poisson, inverse gamma and the normal distribution to generate signal values. Then we analysed our signal values, performing hypothesis tests and calculating maximum likelihood scores in order to determine where modifications are likely to be on the mRNA chain. This year, after gaining valuable biological insight at the Laboratory of Immune Diversity in the German Cancer Research Centre in Heidelberg, I have created a greedy search algorithm to maximise our likelihood score and detect RNA modifications from the signal data. To improve the accuracy, we included a posterior likelihood calculation into our score and I also coded a birth-death algorithm. Then, I tested both methods with multiple reads (signal lists) per mRNA type which proved to be more accurate and created interesting results!</text>
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              <text>This article seeks to understand the importance of identity in impacting the French East India Company by taking as its subject François Caron (1600-1673), a foreigner and one of the first directors of this fledgling company. Caron, as a protestant and former employee of the Dutch East India Company, provides a unique example as to how both religious and national identity permeated 17th century commerce and affected decisions both in Europe and Asia. In the case of the French East India Company, Caron provided some of the impetus within the company to hire a range of foreigners which contributed to a multi-confessional organisation. Identity, however, remained a key source of difference and in Caron’s case would lead to suspicions and accusations of impropriety from his French colleagues. This ties into the historiographical question of the principal-agent-problem and whether Caron acted in the company’s best interests as his loyalty came under scrutiny. Caron came to be heavily relied upon by both Jean-Baptiste Colbert and Louis XIV who invested Caron with an unquestionable authority that would have significant consequences for Caron’s climactic decision to establish a French presence on Ceylon in 1672. </text>
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